GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11248850 | 1 | rs11865131 | chr16:163667 | SNRNP25 | chr16:103829-107668:+ | -0.1 | -3.43 | 0.000629 | Red blood cell traits |
| BRCA | cis | rs8072100 | 1 | rs11870935 | chr17:45732605 | C17orf57 | chr17:45401142-45518675:+ | -0.29 | -10.24 | 1.61E-23 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BRCA | cis | rs8072100 | 1 | rs11870935 | chr17:45732605 | TBKBP1 | chr17:45772630-45789427:+ | 0.14 | 4.33 | 1.63E-5 | Very long-chain saturated fatty acid levels (fatty acid 20:0) |
| BRCA | cis | rs11622475 | 1 | rs1187446 | chr14:104409896 | TDRD9 | chr14:104394817-104519002:+ | 0.43 | 10.87 | 3.47E-26 | Bipolar disorder |
| BRCA | cis | rs11622475 | 1 | rs1187448 | chr14:104406627 | TDRD9 | chr14:104394817-104519002:+ | 0.39 | 10.14 | 3.91E-23 | Bipolar disorder |
| BRCA | cis | rs11082321 | 1 | rs11875806 | chr18:20777414 | C18orf45 | chr18:20777720-21017925:- | -0.2 | -3.85 | 0.000126 | Breast cancer |
| BRCA | cis | rs11082321 | 1 | rs11875806 | chr18:20777414 | NPC1 | chr18:21108363-21166581:- | -0.21 | -4.89 | 1.19E-6 | Breast cancer |
| BRCA | cis | rs11082321 | 1 | rs11875806 | chr18:20777414 | RBBP8 | chr18:20513295-20606445:+ | -0.15 | -3.6 | 0.000337 | Breast cancer |
| BRCA | cis | rs7246967 | 1 | rs11879853 | chr19:23029434 | ZNF492 | chr19:22817126-22850472:+ | 0.24 | 5.55 | 3.7E-8 | Bronchopulmonary dysplasia |
| BRCA | cis | rs4803468 | 1 | rs11880539 | chr19:41918949 | B3GNT8 | chr19:41931265-41934635:- | 0.22 | 6.84 | 1.37E-11 | Height |
| BRCA | cis | rs11880637 | 1 | rs11880637 | chr19:11655010 | ELOF1 | chr19:11663858-11670051:- | 0.19 | 3.42 | 0.000652 | IgG glycosylation |
| BRCA | cis | rs11880637 | 1 | rs11880637 | chr19:11655010 | ILF3 | chr19:10764937-10803093:+ | 0.17 | 3.41 | 0.000679 | IgG glycosylation |
| BRCA | cis | rs4803480 | 1 | rs11882144 | chr19:42072602 | CEACAM21 | chr19:42055886-42093196:+ | 0.5 | 14.66 | 1.89E-44 | Schizophrenia |
| BRCA | cis | rs7246967 | 1 | rs11882498 | chr19:23060012 | ZNF492 | chr19:22817126-22850472:+ | -0.21 | -4.64 | 3.86E-6 | Bronchopulmonary dysplasia |
| BRCA | cis | rs4803468 | 1 | rs11883104 | chr19:41923799 | B3GNT8 | chr19:41931265-41934635:- | -0.24 | -7.34 | 4.37E-13 | Height |